S036 Inflammatory Skin Diseases: The Translational Revolution
DESCRIPTION
In the past decade we experienced a revolution in the mechanistic understanding of inflammatory skin diseases. This translational revolution started with psoriasis, and is now extending to many other common inflammatory skin diseases, and particularly atopic dermatitis, alopecia areata, vitiligo, hidradenitis suppurativa, pustular psoriasis, and acne/rosacea. These advances are now translating to rapid development and testing in early and late stage clinical trials of more narrow, targeted treatments for these diseases, that are safer for long-term disease control than older, primarily immune suppressant treatments. In this symposium we will address both the increased understanding and the novel therapeutic developments for common inflammatory skin diseases that we see in daily practice, that ultimately will improve patient care.
LEARNING OBJECTIVES
Identify the immune axes involved in common inflammatory skin diseases.
Recognize how different treatment approaches work in various inflammatory diseases.
Describe the commonalities between various inflammatory skin diseases and how new treatments may commonly treat them. Apply new knowledge to improving future treatments.
SCHEDULE
1:00 PM
introduction
Emma Guttman, MD, PhD, FAAD
1:05 PM
Psoriasis: the gold standard for therapeutic advances
Bruce Elliot Strober, MD, PhD, FAAD
1:30 PM
Atopic Dermatitis-New insights and therapeutic developments
Emma Guttman, MD, PhD, FAAD
1:55 PM
Alopecia Areata: New treatments and developments
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
2:20 PM
Hidradenitis Suppurativa—Updates and new treatments
James G. Krueger, MD, PhD, FAAD
2:45 PM
Vitiligo: Evolving insights and new treatment approaches
David Rosmarin, MD, FAAD
3:10 PM
Acne and Rosacea: New Frontiers
Linda F. Stein Gold, MD, FAAD
3:35 PM
Q&A
DIRECTOR
Emma Guttman, MD, PhD, FAAD
SPEAKERS
James G. Krueger, MD, PhD, FAAD
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
David Rosmarin, MD, FAAD
Linda F. Stein Gold, MD, FAAD
Bruce Elliot Strober, MD, PhD, FAAD
DISCLOSURES
Emma Guttman, MD, PhD, FAAD
AbbVie – Consultant(Fees), Consultant(Honoraria); Almirall – Consultant(Fees); Amgen – Consultant(Fees), Investigator(Grants/Research Funding); AnaptysBio – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apollo Therapeutics Ltd – Investigator(Grants/Research Funding); Artax Biopharma – Consultant (1099 relationship)(Fees); Astria Therapeutics – Consultant (1099 relationship)(Fees); Bambusa Therapeutics Inc – Consultant (1099 relationship)(Fees); Biolojic Design – Consultant (1099 relationship)(Fees); Bionyra Pharma – Consultant (1099 relationship)(Fees); Boehringer Ingelheim – Consultant(Fees); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Celldex – Consultant (1099 relationship)(Fees); Cue Biopharma – Consultant (1099 relationship)(Fees); CytoReason – Consultant (1099 relationship)(Fees); DBV Technologies – Consultant (1099 relationship)(Fees); Dualitas Therapeutics – Consultant (1099 relationship)(Fees); Electra Therapeutics – Consultant (1099 relationship)(Fees); Eli Lilly and Company – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); EMD Serono – Consultant (1099 relationship)(Fees); Enveda Biosciences – Consultant (1099 relationship)(Fees); Evommune, Inc. – Consultant (1099 relationship)(Fees); Galderma Research & Development, LLC – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Generate Biomedicines – Consultant (1099 relationship)(Fees); Gilead Sciences, Inc – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Infimmune – Consultant (1099 relationship)(Fees); Inmagene Biopharmaceuticals – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Janssen – Consultant (1099 relationship)(Fees); Jasper Therapeutics – Consultant (1099 relationship)(Fees); Kymera Therapeutics – Consultant (1099 relationship)(Fees); Kyowa Hakko Kirin Pharma, Inc. – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Matchpoint Therapeutics – Consultant (1099 relationship)(Fees); Merck – Consultant(Fees), Consultant(Honoraria); Navigator Medicines – Consultant (1099 relationship)(Fees); Nektar Therapeutics – Consultant (1099 relationship)(Fees); Opsidio – Investigator(Grants/Research Funding); Pfizer Inc. – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Propeller Bio – Consultant (1099 relationship)(Fees); Proteologix US Inc – Consultant (1099 relationship)(Fees); RAPT Therapeutics – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria), Consultant (1099 relationship)(Stock Options), Investigator(Grants/Research Funding); RayThera – Consultant (1099 relationship)(Fees); Regeneron – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Rubedo Life Sciences – Consultant (1099 relationship)(Fees); Sanofi – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); SATO Pharmaceutical Co., Ltd – Consultant(Fees); Sitryx – Consultant (1099 relationship)(Fees); Sun Pharma Advanced Research Company (SPARC) – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Fees); Teva – Consultant (1099 relationship)(Fees); TRex Bio – Consultant (1099 relationship)(Fees); Triveni Bio – Consultant (1099 relationship)(Fees); UCB – Consultant(Fees), Investigator(Grants/Research Funding); Ventyx Biosciences – Consultant (1099 relationship)(Fees); VeraDermics Inc. – Consultant (1099 relationship)(Fees); VRG Therapeutics – Consultant (1099 relationship)(Fees); Xencor – Consultant (1099 relationship)(Fees);
James G. Krueger, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Allergan, Inc. – Consultant(Honoraria); Almirall – Consultant (1099 relationship)(Honoraria); Alumis – Consultant (1099 relationship)(Honoraria); Amgen – Consultant(Honoraria), Investigator(Grants/Research Funding); Aristea Therapeutics – Consultant(Honoraria); Artax Biopharma – Consultant(Honoraria), Investigator(Grants/Research Funding); Avillion – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria), Investigator(Grants/Research Funding); Calliditas Therapeutics – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Consultant(Honoraria); EMD Serono – Consultant (1099 relationship)(Honoraria); Evommune, Inc. – Consultant (1099 relationship)(Honoraria); Incyte – Consultant (1099 relationship)(Honoraria); Innovaderm Research Inc. – Consultant (1099 relationship)(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria); Kymera Therapeutics – Consultant (1099 relationship)(Honoraria); Kyowa Kirin – Consultant(Honoraria); MC2 Therapeutics A/S – Consultant (1099 relationship)(Honoraria); Merck – Consultant (1099 relationship)(Honoraria); MoonLake Immunotherapeutics – Consultant(Honoraria); Navigator Medicines – Consultant (1099 relationship)(Honoraria); Novartis – Investigator(Grants/Research Funding); Novartis Pharmaceuticals Corp. – Consultant(Honoraria); Nuvig Therapeutics – Consultant (1099 relationship)(Honoraria); ONO-Pharma – Investigator(Grants/Research Funding); Oruka Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Provectus Pharmaceuticals – Investigator(Grants/Research Funding); Regeneron – Investigator(Grants/Research Funding); Sanofi US Services – Consultant(Honoraria); Schro¨dinger, Inc – Consultant (1099 relationship)(Honoraria); Sudo Biosciences – Investigator(Grants/Research Funding); Sun Pharmaceutical Industries Ltd. – Consultant(Honoraria); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Target-Derm – Consultant(Honoraria); UCB – Consultant(Honoraria), Investigator(Grants/Research Funding); Union Therapeutics – Consultant (1099 relationship)(Honoraria); Valeant Pharmaceuticals International – Consultant (1099 relationship)(Honoraria); Valeant Pharmaceuticals North America LLC – Consultant(Honoraria); Ventyx Biosciences – Consultant(Honoraria), Investigator(Grants/Research Funding); Vitae Pharmaceuticals – Investigator(Grants/Research Funding); Zomagen Biosciences – Investigator(Grants/Research Funding);
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
AbbVie – Investigator(No Compensation Received); Arcutis, Inc. – Investigator(No Compensation Received); Arena Pharmaceuticals – Advisory Board(Honoraria), Investigator(No Compensation Received); Concert Pharmaceuticals – Advisory Board(Honoraria); Eli Lilly – Speaker(Honoraria); Kyowa Hakko Kirin Pharma, Inc. – Investigator(No Compensation Received); La Roche-Posay Laboratorie Pharmaceutique – Advisory Board(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria), Investigator(No Compensation Received); Merz Aesthetics – Investigator(Grants/Research Funding); Nutrafol – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding);
David Rosmarin, MD, FAAD
AbbVie – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Abcuro, Inc. – Consultant(Honoraria); Almirall – Consultant (1099 relationship)(Honoraria); AltruBio Inc. – Consultant(Honoraria); Amgen – Speaker(Honoraria); Arena Pharmaceuticals – Consultant(Honoraria); Boehringer Ingelheim – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Celgene – Investigator(Grants/Research Funding); Celgene Corporation – Advisory Board(Honoraria), Speaker(Honoraria); Concert Pharmaceuticals – Consultant(Honoraria), Data Safety Monitoring Board(Honoraria); CSL Behring – Consultant(Honoraria); Dermavant Sciences – Advisory Board(Honoraria), Speaker(Honoraria); Dermira – Consultant(Honoraria); Incyte Corporation – Consultant(Honoraria), Investigator(Grants/Research Funding), Other(Other Financial Benefit), Speaker(Honoraria); Janssen Biotech – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Kyowa Hakko Kirin Pharma, Inc. – Consultant(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Merck & Co., Inc – Investigator(Grants/Research Funding); Nektar Therapeutics – Consultant (1099 relationship)(Honoraria); Novartis – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); RAPT Therapeutics – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Recludix Pharma – Consultant (1099 relationship)(Honoraria); Regeneron – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Revolo Therapeutics – Consultant(Honoraria); Sanofi – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Consultant(Honoraria); UCB – Advisory Board(Honoraria); Viela Bio – Advisory Board(Honoraria); Zura Bio – Consultant (1099 relationship)(Honoraria);
Linda F. Stein Gold, MD, FAAD
AbbVie – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Actavis – Speaker(Honoraria); Almirall – Advisory Board(Honoraria), Speaker/Faculty Education(Honoraria); Alumis – Investigator(Grants/Research Funding); AnaptysBio – Consultant(Grants/Research Funding), Investigator(Grants/Research Funding); BMS – Consultant(Honoraria), Speaker(Honoraria); Botanix Pharmaceuticals – Consultant(Honoraria); Cutera, Inc. – Consultant(Honoraria); Galderma Laboratories, L.P. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Incyte Corporation – Advisory Board(Honoraria), Consultant(Honoraria); Janssen Scientific Affairs, LLC – Consultant(Honoraria); Journey Medical Corporation – Investigator(Grants/Research Funding); Kymera Therapeutics – Advisory Board(Honoraria); La Roche-Posay Laboratorie Pharmaceutique – Advisory Board(Honoraria); Leo Pharma Inc. – Investigator(Grants/Research Funding); LEO Pharma, US – Advisory Board(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria); Novartis Pharmaceuticals Corp. – Investigator(Grants/Research Funding); Oruka Therapeutics – Investigator(Grants/Research Funding); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker/Faculty Education(Honoraria); Promius Pharmaceuticals – Advisory Board(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Speaker/Faculty Education(Honoraria); Sun Pharmaceutical Industries Ltd. – Speaker(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); Taro Pharm – Advisory Board(Honoraria), Consultant(Honoraria); UCB – Consultant(Honoraria); Valeant Pharmaceuticals International – Advisory Board(Honoraria), Investigator(Grants/Research Funding);
Bruce Elliot Strober, MD, PhD, FAAD
AbbVie – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Alumis – Consultant(Fees); Amgen – Consultant (1099 relationship)(Fees); Arcutis, Inc. – Consultant(Fees), Speaker(Honoraria); Boehringer Ingelheim – Consultant(Honoraria); Bristol Myers Squibb – Speaker(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Connect Biopharma LLC – Stockholder(Other Financial Benefit); CoreEvitas, LLC – Advisory Board(Honoraria), Investigator(Fees); Eli Lilly and Company – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Johnson and Johnson – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees), Speaker(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Honoraria); Meiji Seika Pharma Co., Ltd – Consultant(Fees); Mindera – Stockholder(Other Financial Benefit); Novartis Pharmaceuticals Corp. – Advisory Board(Honoraria), Consultant(Honoraria); Oruka Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); UCB – Advisory Board(Honoraria), Consultant(Fees), Speaker(Honoraria);