F022 Structure and Function of the Skin: Development, Cell Biology, and Skin Structure
DESCRIPTION
This session offers a high-yield, clinically relevant overview of basic science and immunology concepts essential to understanding and managing dermatologic conditions. Topics include genodermatoses, blistering disorders, inflammatory skin diseases, pigmentary disorders, carcinogenesis, pruritus, and skin aging. Participants will explore key concepts such as embryologic skin development, organization and structure of the basement membrane, keratinocyte and melanocyte biology, innate and adaptive immune mechanisms in the skin, molecular pathways of carcinogenesis, and the clinical implications of immunosenescence. Designed for medical students, residents, practicing dermatologists, or researchers, this focused session bridges basic science with clinical practice to reinforce the fundamentals of cutaneous biology.
LEARNING OBJECTIVES
Recall the general stages of cutaneous development and describe the complex structural organization of the skin.
Explain various innate and adaptive immune mechanisms in the skin that contribute to cutaneous dysbiosis, immune homeostasis, and the development of common, inflammatory skin conditions.
Describe the major mechanisms underlying cutaneous itch, skin carcinogenesis, cellular immunosenescence, and skin-related changes observed in aging adults.
SCHEDULE
9:00 AM
Introduction
Jason Ezra Hawkes, MD, MS, FAAD
9:05 AM
Development and Structural Organization of the Skin: Clinical Observations from Pediatric Dermatology
Elizabeth A. Swanson, MD, FAAD
9:25 AM
Keratinocyte Biology, Barrier Function, and the Microbiome: A Template for Type 2 Inflammatory Skin Disease
Raj J. Chovatiya, MD, PhD, FAAD
9:45 AM
Cutaneous Immunity: Insights About Psoriasis, Alopecia Areata, and Hidradenitis Suppurativa Pathogenesis
Jason Ezra Hawkes, MD, MS, FAAD
10:05 AM
Melanocytes and Cutaneous Disorders of Pigmentation: Skin Carcinogenesis and Vitiligo
Benjamin David Ehst, MD, PhD, FAAD
10:25 AM
Cutaneous Immunosenescence and Itch: The Science Clinical Relevance of Skin Aging
Daniel Charles Butler, MD, FAAD
10:45 AM
Panel Q&A and Conclusion
DIRECTOR
Jason Ezra Hawkes, MD, MS, FAAD
SPEAKERS
Daniel Charles Butler, MD, FAAD
Raj J. Chovatiya, MD, PhD, FAAD
Benjamin David Ehst, MD, PhD, FAAD
Elizabeth A. Swanson, MD, FAAD
DISCLOSURES
Daniel Charles Butler, MD, FAAD
AbbVie – Investigator(Grants/Research Funding); Galderma – Advisory Board(Fees); Leo Pharma Inc – Advisory Board(Fees); Novartis – Advisory Board(Honoraria); Pfizer Inc. – Investigator(Grants/Research Funding); Regeneron – Speaker(Honoraria);
Raj J. Chovatiya, MD, PhD, FAAD
AbbVie – Consultant(Fees), Speaker(Honoraria); Acelyrin – Consultant (1099 relationship)(Fees); Alumis – Consultant (1099 relationship)(Fees); Amgen – Consultant (1099 relationship)(Fees); Apogee Therapeutics – Consultant(Fees); Arcutis Biotherapeutics – Consultant(Fees), Speaker(Fees); arGEN-X – Consultant(Fees); ASLAN Pharmaceuticals – Consultant(Fees); Astria Therapeutics – Consultant (1099 relationship)(Fees); Avalere Health – Consultant (1099 relationship)(Honoraria); Beiersdorf, Inc. – Consultant(Fees), Speaker(Fees); Boehringer Ingelheim – Consultant(Fees), Speaker(Honoraria); Bristol-Myers Squibb – Consultant(Fees), Speaker(Honoraria); Cara Therapeutics – Consultant(Fees); Castle Biosciences – Consultant (1099 relationship)(Fees); Dermavant Sciences – Consultant(Fees), Speaker(Fees); Eli Lilly and Company – Consultant(Fees), Investigator(Grants/Research Funding), Speaker(Fees); EMD Serono – Consultant (1099 relationship)(Fees); Formation Bio – Consultant (1099 relationship)(Fees); Foundation for Research & Education of Dermatology – Speaker/Faculty Education(Honoraria); Galderma – Consultant (1099 relationship)(Fees), Speaker(Fees); Genentech, Inc. – Consultant(Fees); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Johnson & Johnson Innovative Medicine – Consultant (1099 relationship)(Fees); Kenvue – Consultant (1099 relationship)(Fees); L'Oreal USA Inc. – Consultant (1099 relationship)(Fees); Leo Pharma Inc. – Consultant(Fees), Speaker(Fees); Maui Derm – Speaker/Faculty Education(Honoraria); National Eczema Association – Speaker/Faculty Education(Honoraria); Nektar Therapeutics – Consultant (1099 relationship)(Fees); Novartis – Speaker(Fees); Opsidio – Consultant (1099 relationship)(Fees); Pfizer Inc. – Consultant(Fees), Speaker(Fees); RAPT Therapeutics – Consultant (1099 relationship)(Fees); Regeneron – Consultant(Fees), Speaker(Fees); Sanofi – Consultant(Fees), Speaker(Fees); Sitryx – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Fees); TRex Bio – Consultant (1099 relationship)(Fees); UCB – Consultant(Fees), Speaker(Honoraria);
Benjamin David Ehst, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Acelyrin – Investigator(Grants/Research Funding); Allakos – Investigator(Grants/Research Funding); Alumis – Investigator(Grants/Research Funding); Amgen – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); AnaptysBio – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Apogee Therapeutics – Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Consultant(Honoraria), Investigator(Grants/Research Funding); BMS – Investigator(Grants/Research Funding), Speaker(Honoraria); Celldex – Investigator(Grants/Research Funding); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Dermavant Sciences – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); DermBiont – Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Incyte – Consultant (1099 relationship)(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding), Speaker(Honoraria); Janssen Biotech – Consultant(Honoraria), Investigator(Grants/Research Funding); Kymab – Investigator(Grants/Research Funding); Leo Pharma A/S – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); National Psoriasis Foundation – Speaker/Faculty Education(Honoraria); Navigator Medicines – Consultant (1099 relationship)(Honoraria); Novartis – Consultant(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Investigator(Grants/Research Funding); Proivant – Consultant(Honoraria); Sanofi/Regeneron – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Investigator(Grants/Research Funding); Takeda Pharmaceuticals USA Inc – Investigator(Grants/Research Funding); UCB – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); UpToDate, Inc. – Other(Patent royalties or other compensation for Intellectual Property Rights); Ventyx Biosciences – Investigator(Grants/Research Funding);
Jason Ezra Hawkes, MD, MS, FAAD
AbbVie – Advisory Board(Fees), Investigator(Grants/Research Funding); Acelyrin – Investigator(Grants/Research Funding); Alumis – Investigator(Grants/Research Funding); Amgen – Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(No Compensation Received), Investigator(Grants/Research Funding); Arcutis, Inc. – Advisory Board(Fees); Blueprint Medicines – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Boehringer Ingelheim – Advisory Board(Fees), Speaker(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Speaker(Honoraria); Celldex – Investigator(Grants/Research Funding); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Dermavant Sciences, Inc. – Advisory Board(Honoraria); Eli Lilly and Company – Advisory Board(Fees), Investigator(Grants/Research Funding), Speaker(Honoraria); Galderma – Advisory Board(Honoraria), Speaker(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); LEO Laboratories Ltd (LEO Pharma) – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Novartis – Advisory Board(Fees), Speaker/Faculty Education(Honoraria); Oruka Therapeutics – Investigator(Grants/Research Funding); Regeneron Pharmaceuticals, Inc. – Advisory Board(Honoraria), Speaker(Honoraria), Stockholder(Stock); Sanofi Genzyme – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Takeda Pharmaceuticals USA Inc – Investigator(Grants/Research Funding); UCB – Consultant(Fees), Speaker(Honoraria);
Elizabeth A. Swanson, MD, FAAD
AbbVie – Advisory Board(Honoraria), Speaker(Honoraria); Almirall – Advisory Board(Honoraria); Alphyn Biologics – Advisory Board(Honoraria); Arcutis, Inc. – Advisory Board(Honoraria), Speaker(Honoraria); Boehringer Ingelheim – Advisory Board(Honoraria); Castle Biosciences – Advisory Board(Honoraria); Chiesi Farmaceutici – Advisory Board(Honoraria); Dermavant Sciences – Advisory Board(Honoraria); Dermavant Sciences, Inc. – Speaker(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Speaker(Honoraria); Galderma – Advisory Board(Honoraria), Speaker(Honoraria); Incyte – Advisory Board(Honoraria); Incyte Corporation – Speaker(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Speaker(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria); Organon – Advisory Board(Honoraria), Speaker(Honoraria); Pelthos Therapeutics – Advisory Board(Honoraria), Speaker(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Speaker(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Speaker(Honoraria); Verrica Pharmaceuticals Inc – Advisory Board(Honoraria), Speaker(Honoraria);