S016 Atopic Dermatitis
DESCRIPTION
Up-to-date overview about atopic dermatitis, new discoveries, and new therapies. The session is directed towards dermatologists/health providers who treat atopic dermatitis. Moderated by Drs. Paller and Drucker, Topics are: Epidemiology of Atopic Dermatitis (Dr. Drucker); Epidermal Barrier and Immune Dysregulation (Dr. Beck); Atopic Dermatitis and the Atopic March (Dr. Leung); Pathogenesis of Itch and its Treatment (Dr. Kim); Topical Therapy (Dr. Eichenfield); Systemics for Pediatric Patients (Dr Paller); and Systemic Therapy for Adults, including Emerging Therapies (Dr. Simpson). Participants are encouraged to bring questions for panel discussion.
LEARNING OBJECTIVES
Recognize the high burden of atopic dermatitis
Identify barrier, neurologic, and immune shifts in atopic dermatitis that form the basis for new therapies
Use the available and emerging therapies in making decisions about atopic dermatitis management
SCHEDULE
1:00 PM
Introduction
Amy S. Paller, MD, FAAD, Aaron Mark Drucker, MD, FAAD
1:05 PM
Epidemiology of Atopic Dermatitis
Aaron Mark Drucker, MD, FAAD
1:15 PM
Epidermal Barrier and Immune Dysregulation
Lisa A Beck, MD, FAAD
1:40 PM
The Atopic March: Can We Prevent It?
Donald Leung
2:00 PM
Pathogenesis and Treatment of Itch in Atopic Dermatitis
Brian S Kim, MD, FAAD
2:20 PM
Topical Therapy
Lawrence F Eichenfield, MD, FAAD
2:50 PM
Systemics for Pediatric Patients
Amy S. Paller, MD, FAAD
3:15 PM
Systemic Therapy for Adults - Available and Emerging
Eric Lawrence Simpson, MD, FAAD
3:45 PM
Panel Discussion
DIRECTOR
Amy S. Paller, MD, FAAD
CO-DIRECTOR
Aaron Mark Drucker, MD, FAAD
SPEAKERS
Lisa A Beck, MD, FAAD
Lawrence F Eichenfield, MD, FAAD
Brian S Kim, MD, FAAD
Donald Leung
Eric Lawrence Simpson, MD, FAAD
DISCLOSURES
Lisa A Beck, MD, FAAD
AbbVie – Consultant(Fees), Investigator(Grants/Research Funding); Allakos – Advisory Board(Honoraria); AMGEN – Consultant (1099 relationship)(Honoraria); Arcutis Biotherapeutics – Consultant (1099 relationship)(Honoraria); Arena Pharmaceuticals – Advisory Board(Honoraria); ASLAN Pharmaceuticals – Consultant (1099 relationship)(Honoraria); AstraZeneca – Consultant(Fees), Investigator(Grants/Research Funding); Astria Therapeutics – Consultant (1099 relationship)(Honoraria); Belharra Therapeutics – Consultant (1099 relationship)(Honoraria); Celldex – Consultant (1099 relationship)(Honoraria); Dermavent – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Consultant(Fees); Escient Pharmaceuticals, Inc – Consultant (1099 relationship)(Honoraria); Galderma Research & Development, LLC – Advisory Board(Honoraria); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Honoraria); Invea Therapeutics – Consultant (1099 relationship)(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria); LEO Laboratories Ltd (LEO Pharma) – Consultant(Fees); Medtronics – Stockholder(Stock); Merck & Co., Inc – Advisory Board(Honoraria); Nektar Therapeutics – Advisory Board(Honoraria); Novartis – Consultant(Fees); NUMAB Therapeutics AG – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); RAPT Therapeutics – Consultant(Honoraria); Regeneron – Consultant(Fees); Regeneron Pharmaceuticals, Inc. – Investigator(Grants/Research Funding); ResVita Bio, Inc – Consultant (1099 relationship)(Honoraria); Ribon Therapeutics – Consultant(Honoraria); Sanofi – Consultant(Fees), Investigator(Grants/Research Funding); Sitryx Therapeutics – Consultant (1099 relationship)(Honoraria); Stealth Biotherapeutics – Consultant (1099 relationship)(Honoraria); TRex Bio – Consultant (1099 relationship)(Honoraria); Triveni Bio – Consultant (1099 relationship)(Honoraria); UCB Pharma – Consultant (1099 relationship)(Honoraria); Union Therapeutics – Consultant (1099 relationship)(Honoraria); Xencor – Consultant (1099 relationship)(Honoraria);
Aaron Mark Drucker, MD, FAAD
No financial relationships exist with ineligible companies.
Lawrence F Eichenfield, MD, FAAD
AbbVie – Consultant(Honoraria); Abbvie – Investigator(Grants/Research Funding); Abeona Therapeutics – Consultant (1099 relationship)(Honoraria); Acrotech Biopharma Inc – Consultant (1099 relationship)(Honoraria); Almirall – Consultant(Honoraria); Amgen – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Amryt Pharma – Consultant(Honoraria); Apogee Therapeutics – Consultant (1099 relationship)(Honoraria); Arcutis Biotherapeutics – Investigator(Grants/Research Funding); Arcutis, Inc. – Consultant (1099 relationship)(Honoraria); Attovia Therapeutics – Consultant (1099 relationship)(Fees); Bristol-Myers Squibb – Consultant(Honoraria); Castle Biosciences – Consultant (1099 relationship)(Honoraria); Castle Biosciences, Inc – Investigator(Grants/Research Funding); Chiesi Farmaceutici – Consultant (1099 relationship)(Honoraria); Dermata Therapeutics – Consultant (1099 relationship)(Stock); Dermavant Sciences, Inc. – Consultant(Honoraria); Eli Lilly – Consultant(Honoraria), Investigator(Grants/Research Funding); Elsevier Inc. – Other(Patent royalties or other compensation for Intellectual Property Rights); Forte Biosciences – Board of Directors(Fees), Board of Directors(Stock Options); Galderma Laboratories, L.P. – Consultant(Honoraria), Investigator(Fees); Incyte Corporation – Consultant(Honoraria); Janssen Pharmaceuticals, Inc – Consultant (1099 relationship)(Honoraria); Kenvue – Consultant (1099 relationship)(Honoraria); Krystal Biotech, Inc – Consultant(Honoraria); Kymera Therapeutics – Consultant (1099 relationship)(Honoraria); LEO Pharma, US – Consultant(Honoraria), Investigator(Fees); Lilly ICOS LLC – Consultant(Honoraria); Novartis – Consultant (1099 relationship)(Honoraria); Organon – Consultant (1099 relationship)(Honoraria); Ortho Dermatologics – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Sanofi/Regeneron – Consultant(Honoraria), Investigator(Fees); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria); Target RWE – Investigator(Grants/Research Funding); TopMD – Consultant(Stock Options); TRex Bio – Consultant (1099 relationship)(Honoraria); TrialSpark, Inc. – Consultant(Honoraria); UCB – Consultant(Honoraria); Verrica Pharmaceuticals Inc – Board of Directors(Fees), Board of Directors(Stock Options); Wiley-Blackwell – Other(Honoraria);
Brian S Kim, MD, FAAD
23andMe – Consultant (1099 relationship)(Fees); AbbVie – Consultant(Fees); Almirall – Advisory Board(Honoraria); Amagma Therapeutics – Consultant(Fees); Amgen – Consultant (1099 relationship)(Fees); Arcutis Biotherapeutics – Consultant (1099 relationship)(Fees); AstraZeneca – Consultant (1099 relationship)(Fees); Bellus Health – Advisory Board(Honoraria); Blueprint Medicines – Board of Directors(Honoraria); BMS – Consultant(Honoraria); Boehringer Ingelheim – Advisory Board(Honoraria); Cara Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Clexio – Consultant (1099 relationship)(Fees); Daewoong Pharmaceuticals – Consultant(Fees); Eli Lilly and Company – Advisory Board(Honoraria); Escient Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees); Evommune, Inc. – Consultant (1099 relationship)(Fees); Galderma – Consultant (1099 relationship)(Fees); Genentech, Inc. – Consultant (1099 relationship)(Fees); GlaxoSmithKline – Consultant (1099 relationship)(Fees); Granular Therapeutics – Consultant(Fees); Guidepoint Global, LLC – Consultant(Fees); Incyte Corporation – Consultant(Fees); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria); Klirna – Founder(Stock); Klirna Biotech, Inc. – Founder(Stock); Leo Pharma Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Locus Biosciences – Stockholder(Stock); Micreos – Consultant (1099 relationship)(Fees); Novartis – Advisory Board(Honoraria); Nuogen Pharma – Founder(Stock); OM Pharma – Consultant(Fees); Pfizer Inc. – Consultant(Honoraria); Recens Medical – Consultant(Fees); Sanofi – Consultant(Fees); Sanofi Genzyme – Consultant(Fees); Sanofi/Regeneron – Advisory Board(Honoraria); Septerna – Consultant (1099 relationship)(Fees); Shaperon – Consultant(Fees); Teva Pharmaceuticals USA – Advisory Board(Fees); Trevi Therapeutics – Consultant(Fees); VeraDermics Inc. – Investigator(Fees);
Donald Leung
Apollo Therapeutics Ltd – Advisory Board(Fees); Genentech – Investigator(Grants/Research Funding); Jasper Therapeutics – Advisory Board(Fees); Sanofi – Consultant (1099 relationship)(Fees); Sanofi Genzyme – Investigator(Grants/Research Funding); Takeda Pharmaceuticals USA Inc – Advisory Board(Fees); Windward Bio – Advisory Board(Fees);
Amy S. Paller, MD, FAAD
AbbVie – Data Safety Monitoring Board(Honoraria), Investigator(Grants/Research Funding); Abeona Therapeutics – Data Safety Monitoring Board(Honoraria); Arcutis Biotherapeutics – Consultant (1099 relationship)(Honoraria); BioCryst Pharmaceuticals, Inc. – Consultant (1099 relationship)(Honoraria), Data Safety Monitoring Board(Honoraria); BioMendics, LLC – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria); Castle Creek Pharmaceuticals – Consultant (1099 relationship)(Honoraria); Chiesi Farmaceutici – Consultant (1099 relationship)(Honoraria); Daiichi Sankyo – Data Safety Monitoring Board(Honoraria); Dermavant Sciences, Inc. – Investigator(Grants/Research Funding); Eli Lilly – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Galderma – Data Safety Monitoring Board(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Johnson & Johnson Innovative Medicine – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Krystal Biotech, Inc – Consultant(Honoraria); L'Oréal France – Consultant (1099 relationship)(Honoraria); Leo Pharma Inc – Consultant(Honoraria); MoonLake Immunotherapeutics – Consultant (1099 relationship)(Honoraria); Pelthos Therapeutics – Consultant (1099 relationship)(Honoraria); Quoin Pharmaceuticals Ltd – Consultant (1099 relationship)(Honoraria); Regeneron – Consultant(Honoraria), Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Honoraria); UCB – Investigator(Grants/Research Funding);
Eric Lawrence Simpson, MD, FAAD
AbbVie – Consultant(Fees), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Consultant (1099 relationship)(Fees); Acrotech Biopharma Inc – Investigator(Grants/Research Funding); Amgen – Consultant(Fees), Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Consultant(Fees); Arcutis, Inc. – Investigator(Grants/Research Funding); ASLAN – Investigator(Grants/Research Funding); Astria Therapeutics – Consultant (1099 relationship)(Fees); Attovia Therapeutics, Inc – Consultant (1099 relationship)(Fees); Bambusa Therapeutics Inc – Consultant (1099 relationship)(Fees); Castle Biosciences – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); CorEvitas – Consultant(Fees), Investigator(Grants/Research Funding); Demira – Consultant(Fees); Dermavant – Investigator(Grants/Research Funding); Dermira – Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Fees), Investigator(Grants/Research Funding); Evomunne – Consultant (1099 relationship)(Fees); FIDE – Speaker/Faculty Education(Fees); Genentech, Inc. – Consultant (1099 relationship)(Fees); Impetus Healthcare – Consultant (1099 relationship)(Fees); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); Inmagene Biopharmaceuticals – Consultant (1099 relationship)(Fees); Innovaderm Research Inc. – Consultant (1099 relationship)(Fees); Janssen Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees); Kymera Therapeutics – Consultant (1099 relationship)(Fees); La Fonderie Ressources – Consultant (1099 relationship)(Fees); Leo Pharma Inc. – Consultant(Fees); National Jewish Health – Investigator(Grants/Research Funding); NUMAB Therapeutics AG – Consultant (1099 relationship)(Fees); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Recludix Pharma – Consultant (1099 relationship)(Fees); Regeneron – Consultant(Fees), Investigator(Grants/Research Funding); Roche Products Ltd – Consultant (1099 relationship)(Fees); Sanofi – Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Fees), Investigator(Grants/Research Funding); SITRYX – Consultant (1099 relationship)(Fees); Target RWE – Investigator(Grants/Research Funding); Veriskin – Investigator(Grants/Research Funding);