S024 Inflammatory Skin Diseases: The Translational Revolution
DESCRIPTION
In the past decade we experienced a revolution in the mechanistic understanding of inflammatory skin diseases. This translational revolution started with psoriasis, and is now extending to many other common inflammatory skin diseases, and particularly atopic dermatitis, alopecia areata, vitiligo, hidradenitis suppurativa, pustular psoriasis, and acne/rosacea. These advances are now translating to rapid development and testing in early and late stage clinical trials of more narrow, targeted treatments for these diseases, that are safer for long-term disease control than older, primarily immune suppressant treatments. In this symposium we will address both the increased understanding and the novel therapeutic developments for common inflammatory skin diseases that we see in daily practice, that ultimately will improve patient care.
LEARNING OBJECTIVES
Identify the immune axes involved in common inflammatory skin diseases.
Recognize how different treatment approaches work in various inflammatory diseases.
Describe the commonalities between various inflammatory skin diseases and how new treatments may commonly treat them. Apply new knowledge to improving future treatments.
SCHEDULE
9:00 AM
Introduction
Emma Guttman, MD, PhD, FAAD
9:05 AM
Psoriasis: setting the bar high for therapeutic advances
Mark Lebwohl, MD, FAAD
9:30 AM
Atopic Dermatitis: An evolving success story
Emma Guttman, MD, PhD, FAAD
9:55 AM
Marching for a cure in Alopecia areata
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
10:20 AM
Finally getting new treatments into Hidradenitis Suppurative
James G. Krueger, MD, PhD, FAAD
10:45 AM
Transforming Seborrheic Dermatitis and Rosacea Treatments
Benjamin Ungar, MD, FAAD
11:10 AM
Vitiligo—an evolving landscape
John Harris, MD, PhD, FAAD
11:35 AM
Q and A with faculty
DIRECTOR
Emma Guttman, MD, PhD, FAAD
SPEAKERS
John Harris, MD, PhD, FAAD
James G. Krueger, MD, PhD, FAAD
Mark Lebwohl, MD, FAAD
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
Benjamin Ungar, MD, FAAD
HANDOUTS
DISCLOSURES
Emma Guttman, MD, PhD, FAAD
AbbVie – Consultant(Fees), Consultant(Honoraria); Almirall – Consultant(Fees); Amgen – Consultant(Fees), Investigator(Grants/Research Funding); AnaptysBio – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apollo Therapeutics Ltd – Investigator(Grants/Research Funding); Artax Biopharma – Consultant (1099 relationship)(Fees); Astria Therapeutics – Consultant (1099 relationship)(Fees); Bambusa Therapeutics Inc – Consultant (1099 relationship)(Fees); Biolojic Design – Consultant (1099 relationship)(Fees); Bionyra Pharma – Consultant (1099 relationship)(Fees); Boehringer Ingelheim – Consultant(Fees); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Celldex – Consultant (1099 relationship)(Fees); Cue Biopharma – Consultant (1099 relationship)(Fees); CytoReason – Consultant (1099 relationship)(Fees); DBV Technologies – Consultant (1099 relationship)(Fees); Dualitas Therapeutics – Consultant (1099 relationship)(Fees); Electra Therapeutics – Consultant (1099 relationship)(Fees); Eli Lilly and Company – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); EMD Serono – Consultant (1099 relationship)(Fees); Enveda Biosciences – Consultant (1099 relationship)(Fees); Evommune, Inc. – Consultant (1099 relationship)(Fees); Galderma Research & Development, LLC – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Generate Biomedicines – Consultant (1099 relationship)(Fees); Gilead Sciences, Inc – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Infimmune – Consultant (1099 relationship)(Fees); Inmagene Biopharmaceuticals – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Janssen – Consultant (1099 relationship)(Fees); Jasper Therapeutics – Consultant (1099 relationship)(Fees); Kymera Therapeutics – Consultant (1099 relationship)(Fees); Kyowa Hakko Kirin Pharma, Inc. – Advisory Board(Honoraria), Consultant (1099 relationship)(Fees); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Matchpoint Therapeutics – Consultant (1099 relationship)(Fees); Merck – Consultant(Fees), Consultant(Honoraria); Navigator Medicines – Consultant (1099 relationship)(Fees); Nektar Therapeutics – Consultant (1099 relationship)(Fees); Opsidio – Investigator(Grants/Research Funding); Pfizer Inc. – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Propeller Bio – Consultant (1099 relationship)(Fees); Proteologix US Inc – Consultant (1099 relationship)(Fees); RAPT Therapeutics – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria), Consultant (1099 relationship)(Stock Options), Investigator(Grants/Research Funding); RayThera – Consultant (1099 relationship)(Fees); Regeneron – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Rubedo Life Sciences – Consultant (1099 relationship)(Fees); Sanofi – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); SATO Pharmaceutical Co., Ltd – Consultant(Fees); Sitryx – Consultant (1099 relationship)(Fees); Sun Pharma Advanced Research Company (SPARC) – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Fees); Teva – Consultant (1099 relationship)(Fees); TRex Bio – Consultant (1099 relationship)(Fees); Triveni Bio – Consultant (1099 relationship)(Fees); UCB – Consultant(Fees), Investigator(Grants/Research Funding); Ventyx Biosciences – Consultant (1099 relationship)(Fees); VeraDermics Inc. – Consultant (1099 relationship)(Fees); VRG Therapeutics – Consultant (1099 relationship)(Fees); Xencor – Consultant (1099 relationship)(Fees);
John Harris, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Investigator(Grants/Research Funding); Aclaris Therapeutics, Inc. – Consultant(Fees); Aldena Therapeutics – Consultant(Fees), Founder(Stock); Almirall – Consultant(Fees); Alys Pharmaceuticals – Founder(Salary), Stockholder Private Company(Fees); Bain Capital – Consultant (1099 relationship)(Fees); Barinthus Biotherapeutics North America, Inc. – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant (1099 relationship)(Fees); Boxer Capital Management, LLC – Consultant (1099 relationship)(Fees); Cour Pharmaceuticals – Investigator(Grants/Research Funding); Dren Bio – Investigator(Grants/Research Funding); Granular Therapeutics – Consultant(Fees); Incyte Corporation – Investigator(Grants/Research Funding); Klirna Biotech, Inc. – Founder(Stock); Klirna Therapeutics – Founder(Stock); Leo Pharma Inc – Investigator(Grants/Research Funding); NexImmune – Investigator(Grants/Research Funding); Nira Biosciences, Inc. – Consultant(Fees), Founder(Stock); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Villaris Therapeutics, Inc – Founder(Stock), Investigator(Grants/Research Funding); Vimela – Consultant(Honoraria), Stockholder(Stock); Vividion Therapeutics – Consultant (1099 relationship)(Fees);
James G. Krueger, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Allergan, Inc. – Consultant(Honoraria); Almirall – Consultant (1099 relationship)(Honoraria); Alumis – Consultant (1099 relationship)(Honoraria); Amgen – Consultant(Honoraria), Investigator(Grants/Research Funding); Aristea Therapeutics – Consultant(Honoraria); Artax Biopharma – Consultant(Honoraria), Investigator(Grants/Research Funding); Avillion – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria), Investigator(Grants/Research Funding); Calliditas Therapeutics – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Consultant(Honoraria); EMD Serono – Consultant (1099 relationship)(Honoraria); Evommune, Inc. – Consultant (1099 relationship)(Honoraria); Incyte – Consultant (1099 relationship)(Honoraria); Innovaderm Research Inc. – Consultant (1099 relationship)(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria); Kymera Therapeutics – Consultant (1099 relationship)(Honoraria); Kyowa Kirin – Consultant(Honoraria); MC2 Therapeutics A/S – Consultant (1099 relationship)(Honoraria); Merck – Consultant (1099 relationship)(Honoraria); MoonLake Immunotherapeutics – Consultant(Honoraria); Navigator Medicines – Consultant (1099 relationship)(Honoraria); Novartis – Investigator(Grants/Research Funding); Novartis Pharmaceuticals Corp. – Consultant(Honoraria); Nuvig Therapeutics – Consultant (1099 relationship)(Honoraria); ONO-Pharma – Investigator(Grants/Research Funding); Oruka Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Provectus Pharmaceuticals – Investigator(Grants/Research Funding); Regeneron – Investigator(Grants/Research Funding); Sanofi US Services – Consultant(Honoraria); Schro¨dinger, Inc – Consultant (1099 relationship)(Honoraria); Sudo Biosciences – Investigator(Grants/Research Funding); Sun Pharmaceutical Industries Ltd. – Consultant(Honoraria); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Target-Derm – Consultant(Honoraria); UCB – Consultant(Honoraria), Investigator(Grants/Research Funding); Union Therapeutics – Consultant (1099 relationship)(Honoraria); Valeant Pharmaceuticals International – Consultant (1099 relationship)(Honoraria); Valeant Pharmaceuticals North America LLC – Consultant(Honoraria); Ventyx Biosciences – Consultant(Honoraria), Investigator(Grants/Research Funding); Vitae Pharmaceuticals – Investigator(Grants/Research Funding); Zomagen Biosciences – Investigator(Grants/Research Funding);
Mark Lebwohl, MD, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Added Health – Consultant (1099 relationship)(Honoraria); Aikium – Consultant (1099 relationship)(Honoraria); Almirall – Consultant(Honoraria); AltruBio Inc. – Consultant(Honoraria); Alumis – Consultant (1099 relationship)(Honoraria); Amgen – Consultant (1099 relationship)(Honoraria); Apogee Therapeutics – Consultant(Honoraria); Arcutis, Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); AstraZeneca – Consultant (1099 relationship)(Honoraria); Atomwise – Consultant(Honoraria); Avotres, Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol Myers Squibb – Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria); Cara Therapeutics – Investigator(Grants/Research Funding); Castle Biosciences, Inc – Consultant(Honoraria); Celltrion – Consultant(Honoraria); Clexio Biosciences, Ltd – Investigator(Grants/Research Funding); CoreEvitas, LLC – Consultant(Honoraria); Dermavant Sciences – Consultant(Honoraria), Investigator(Grants/Research Funding); Dermsquared – Consultant (1099 relationship)(Honoraria); Edesa Biotech – Consultant (1099 relationship)(Honoraria); Eli Lilly – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Investigator(Grants/Research Funding); Evommune, Inc. – Consultant(Honoraria); Facilitation of International Dermatology Education – Consultant(Honoraria); Forte Biosciences – Consultant(Honoraria); Galderma – Consultant(Honoraria); Genentech, Inc. – Consultant(Honoraria); Incyte Corporation – Consultant(Honoraria), Investigator(Grants/Research Funding); Inozyme Pharma – Investigator(Grants/Research Funding); Janssen Research & Development, LLC – Investigator(Grants/Research Funding); Leo Pharma A/S – Consultant(Honoraria); Mayne Pharma Group – Consultant (1099 relationship)(Honoraria); Meiji Seika Pharma Co., Ltd – Consultant(Honoraria); Mindera – Consultant(Honoraria); Mirum Pharmaceuticals, Inc. – Consultant (1099 relationship)(Honoraria); MoonLake Immunotherapeutics – Consultant (1099 relationship)(Honoraria); New York College of Podiatric Medicine – Speaker/Faculty Education(Honoraria); Oruka Therapeutics – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Revolo Therapeutics – Consultant (1099 relationship)(Honoraria); Sanofi/Regeneron – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Seanergy Maritime Holdings Corp. – Consultant(Honoraria); Strata Skin Sciences – Consultant(Honoraria); Sun Pharmaceutical Industries Ltd. – Consultant (1099 relationship)(Honoraria); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria); Teva Pharmaceutical Industries Ltd. – Consultant (1099 relationship)(Honoraria); Trevi Therapeutics – Consultant(Honoraria); UCB – Investigator(Grants/Research Funding); Verrica Pharmaceuticals Inc – Consultant(Honoraria);
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
AbbVie – Investigator(No Compensation Received); Arcutis, Inc. – Investigator(No Compensation Received); Arena Pharmaceuticals – Advisory Board(Honoraria), Investigator(No Compensation Received); Concert Pharmaceuticals – Advisory Board(Honoraria); Eli Lilly – Speaker(Honoraria); Kyowa Hakko Kirin Pharma, Inc. – Investigator(No Compensation Received); La Roche-Posay Laboratorie Pharmaceutique – Advisory Board(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria), Investigator(No Compensation Received); Merz Aesthetics – Investigator(Grants/Research Funding); Nutrafol – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding);
Benjamin Ungar, MD, FAAD
AbbVie – Advisory Board(Honoraria); Arcutis Biotherapeutics – Advisory Board(Honoraria); Botanix Pharmaceuticals – Advisory Board(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria); Castle Biosciences – Advisory Board(Honoraria); Eli Lilly – Advisory Board(Honoraria); Fresenius Kabi – Advisory Board(Honoraria); Galderma – Advisory Board(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Johnson and Johnson – Advisory Board(Honoraria); Leo Pharma – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Primus Pharmaceuticals – Advisory Board(Honoraria); RAPT Therapeutics – Investigator(Grants/Research Funding); Sanofi – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Target-Derm – Advisory Board(Honoraria); UCB – Advisory Board(Honoraria);